MRCP (UK), FRCP (Glasgow), CCT (Hepatology,UK)
Hepatology, Liver Disease & Transplantation
Director – Hepatology
Brief Profile
Dr. Dinesh Jothimani is a Hepatologist and Gastroenterologist with over 18 years of experience. He completed his MBBS from The Tamil Nadu Dr. M.G.R. Medical University (TNMGRMU) in 2000 and MRCP (UK) from Royal College of Physician, London in 2004. He is a member of the Indian Association for the study of Liver, Indian Society of Gastroenterology, General Medical Council (GMC), UK, European Association of Study of Liver, British Association of Study of Liver and Fellowship in Royal College of Physicians
Educational Qualifications
• FRCP (Glasgow), The Royal College of Physicians and Surgeons, June 2018, Glasgow
• CCT (Hepatology, Gastroenterology & General medicine) West Midlands Deanery, August 2004 to September 2010
• MRCP (UK) The Royal College of Physicians, April 2004, UK
• MBBS Madras Medical College & Government General Hospital Dr MGR Medical University, August 1994 to January 2000, Chennai, India
Affiliations and Memberships
• Royal College of Physicians and Surgeons (RCPS), Glasgow
• Liver Transplant Society of India (LTSI)
• International Liver Transplant Society (ILTS)
• European Association of Study of liver (EASL), since 2009
• Indian Association for the Study of Liver (INASL)
• General Medical Council (GMC) Specialist Register for Hepatology, Gastroenterology & General Medicine, since 2010
• Royal College of Physicians (RCP), London, since 2004
• American Association for the study of Liver (AASLD)
• India Medical Association (IMA)- Honorary secretary (Global hospital branch)
Honors Awards
• Times Health Excellence Award 2020 for Service Excellence in Liver & Gastro Care
Research Publication
Publications
• Liver in Systemic disease: Managing the patient with unexplained abnormal serum liver tests in secondary care-Infectious disease and immunosuppressed patients (Elsevier Text book chapter) February 2022
• Hepatitis NonA-E viruses (text book chapter) INEDSYS Hepatology: A comprehensive Textbook January 2022
• Post-Liver transplant Viral infections (Text book Chapter- submitted Aug 2021)
• NASH: A rapidly increasing indication for Liver transplantation in India JCEH Sep 2021
• Autoimmune hepatitis following COVID vaccination July 2021J Autoimmunity.
• Reply letter: Optimal diagnostic tool for oesophageal varices during COVID-19 June 2021 Clinical Radiology
• COVID-19: Elevated Von Willibrand factor at hospital admission predicts clinical outcome. May 2021 JAPI
• Optimal diagnostic tool for oesophageal varices during COVID-19 March 2021 Clinical Radiology
• Versatility of Anabolic steroids induced Hepatotoxicity. March 2021 JCEH
• Severe jaundice in a COVID-19 patient. February 2021 JCEH
• Therapeutic plasma exchange in EAD. Feb 2021Exp and Clin Transpl
• LTSI guidelines in the management of ALI in Yellow phosphorus poisoning Dec 2020 JCEH
• First report of toxin induced graft injury following LT. Sep 2020 Hepatology
• Post Liver transplant recurrent and de novo viral infections- Best Practice Gastro & Hepatology Sep 2020
• COVID-19: Poor outcomes in patients with Zinc deficiency IJID August 2020
• COVID-19 and decompensated cirrhosis Hep Int August 2020
• Lockdown effects on Liver transplant recipients- Survey. JAPI July 2020
• COVID-19 and Liver. J Hepatology June 2020
• Acute Liver Failure- INASL consensus. JCEH 2020
• Genetics of NASH- Text book chapter 2019
• Post Liver Transplant Refractory Anemia – Case report 2019 JCEH
• Haemospray in difficult variceal bleed- Case report 2018
• Management of post liver transplant recurrent HCV infection with directly acting antiviral drugs (review) D Jothimani, S Govil, M Rela.. Hepatology International 2016
• Delayed serological transfusion reaction due to anti-e. D Sachin, D Jothimani, M Rela. Indian J Haematol and Blood Transfusion.
• Textbook chapter on Liver Regeneration- Elsevier Liver Transplantation September 2015. R Rajalingam, D Jothimani, M Rela
• Role of Mycophenolate mofetil in Autoimmune hepatitis- an observational study. D Jothimani, M Cramp, TJ Cross. JCEH Jun 2014. Volume 4, Issue 3, 221 – 225
• A new era in the management of chronic hepatitis C- A review. D Jothimani, G Chandy, H Conjeevaram. Indian J Gastroenterol. 2013 Mar;32(2):71-9.
• Macrophage secretory products induce an inflammatory phenotype in hepatocytes. Michelle Melino, Victoria L Gadd, Dinesh Jothimani, Andrew D Clouston, Julie R Jonsson, Elizabeth E Powell. World J Gastroenterol 2012 April 21; 18(15): 1732-1744
• Non-invasive assessment of fibrosis in liver grafts due to hepatitis C recurrence. TJ Cross, D Jothimani, M Heneghan, P Harrison Clinical Transplantation 2011 May;25(3):345-51
• Treatment of Autoimmune hepatitis- a review of current and evolving therapies. D Jothimani, M Cramp, J Mitchell, TJ Cross. J Gastroenterol Hepatol. 2010 Nov 15. doi: 10.1111/j.1440-1746.2010.06579
• Re: Early use of TIPS in cirrhotic patients with variceal bleeding- Letter D Jothimani, TJS Cross. N Engl J Med. 2010; 363: 1375-76
• Re: outcome of recurrent hepatitis C virus after liver transplantation in a randomized trial of monotherapy versus triple therapy-Letter. D Jothimani, TJ Cross. Liver Transpl. 2010 May;16(5):68
• Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided stage of fibrosis is considered. McPherson S, Jonsson J..Jothimani D…Powell E J Hepatol. 2009 Aug;51(2):389-9
• An unusual case of gastric erosions. Jothimani D, Zanetto U, R Owen, P Wilson. Gut. 2009 Dec;58(12):1669, 1708
• Effect of ethnicity on the presentation and management of oesophageal and gastric cancers- A UK perspective. Sadler G, Jothimani D, Zanetto U, M Anderson. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):996-100
• Long term immunosuppression for prevention of non-viral disease recurrence. Neuberger J, Jothimani D. Transplantation Proc May 2005; 37(4):1671-4.
• A case report of hypertension associated with hypokalemia and hyponatremia’ Jothimani D, Morgan N, Snape J. CME Geriatric Medicine, 2005; 7(2): 106-107
Trials, studies and audits
• NASH and Liver transplantation- (ongoing 2020)
• Effect of Cardiovascular disease in NASH transplant patients (ongoing 2020)
• COVID-19 and Liver (2020)
• Effect of Lockdown in liver transplant recipients (2020)
• Efficacy of Terlipressin in variceal bleed 2019
• Leukocyte esterase strip test for rapid diagnosis of SBP (2017-18)
• Hepatitis E in post liver transplant patients
• NASH in healthy liver donors (2016)
• Outcome of Acute Liver Failure due to Rat killer poisoning, Global Hospitals, Chennai
• Body mass Index (BMI) and Liver transplantation outcome, Global Hospitals, Chennai
• Markers of significant steatosis in potential liver donors, Global Hospitals, Chennai, India
• Outcome of combined liver kidney transplantation, Global Hospitals, Chennai, India
• TMC-435 study- Protease inhibitor triple therapy in the management of chronic hepatitis C genotype 1 (previous non-responders and relapsers). Principal co-investigator, Derriford Hospital, Plymouth, UK
• Role of Budesonide in Autoimmune hepatitis, Southwest Liver unit, Derriford Hospital, 2010
• ERCP practice Southwest England compared to national standards, Southwest liver unit, Derriford Hospital, 2010
• Efficacy of MMF in refractory Autoimmune hepatitis, Southwest liver unit, Derriford Hospital, 2010
• Effect of weight loss prior to anti-viral response in patients with obesity and chronic hepatitis C infection, Princess Alexandra Hospital, Brisbane, Australia, 2009
• Role of alternatively activated macrophages (Kupffer cells) in obesity related liver injury in patients with chronic hepatitis C infection. Supervised by A/Prof E Powell
• Factors affecting the response to antiviral treatment in chronic hepatitis C –Is there a role for CD163? Supervised by A/Prof E Powell
• Effect of weight loss in obese patients prior to commencing anti- viral treatment for chronic hepatitis C genotype 1. Supervised by A/Prof E Powell
• Role of MRI in the assessment of liver fibrosis. Supervised by A/Prof E Powell
• Role of Portal Tract Lymphoid Tissue (PALT) in Chronic Hepatitis C Cirrhosis. Supervised by Prof D Adams, University of Birmingham
Posters
• Changing trend of liver transplantation in India ILTS 2020 Turkey (meeting cancelled)
• Cardiometabolic risk profile of patients undergoing Liver Transplantation (ILTS 2020 Turkey, meeting cancelled)
• Role of Therapeutic plasma exchange in DILI. INASL 2018
• Non-invasive markers of Liver Fibrosis _ INASL Aug 2018
• Outcome of patients transplanted for AIH – INASL Aug 2018
• Post transplant Parvovirus infection- INASL Aug 2018
• Predictive factors of NAFLD in healthy liver donors, EASL 2016. Barcelona. D Jothimani, S Govil, M Vij, M Rela
• NASH in potential liver donors, ILTS 2016. Seoul. D Jothimani, S Govil, M Vij, M Rela
• Effect of BMI on post-Liver transplantation short-term outcome. ILTS 2014. London. D Jothimani, S Govil, M Rela
• Predictive Factors of significant steatosis in potential liver donors. ILTS 2014 London. D Jothimani, M Srivatsav, S Reddy, M Rela
• Factors predict significant steatosis in potential liver donors EASL 2014 London. D Jothimani, S Reddy, M Rela
• Combined liver kidney transplantation- ILTS 2013 Sydney
• Variations in the presentation of autoimmune hepatitis. INASL 2013
• Liver stiffness measurement by Transient Elastography in Indian patients D Jothimani, GM Chandy INASL 2012
• Budesonide in Autoimmune Hepatitis, Asia-Pacific Association of Study of Liver disease (APASL), Bangkok, Feb 2011 D Jothimani, T Cross, M Cramp, J Mitchell
• A rare complication of acute hepatitis A infection- case study. Asia-Pacific Association of Study of Liver disease (APASL), Bangkok, Feb 2011. D Jothimani, T Cross, M Cramp, J Mitchell
• MMF in Autoimmune Hepatitis, APASL, Bangkok. Feb 2011 D Jothimani, M Cramp, J Mitchell, T Cross
• Mycophenolate mofetil in patients with Autoimmune hepatitis. BASL Edinburgh, September 2010 Gut Sep 2010, vol 59, supp 2, A17. D Jothimani, U Warshow, M Cramp, J Mitchell, T Cross
• Practice of ERCP in Southwest England- A survey across 5 cancer networks. AUGIS, September 2010. D Jothimani, D Bailey, J Isaacs, S Jackson
• Sensitivity of Endoscopic Ultrasound in staging Oesophageal cancer. Midlands Gastro Scientific Meeting, June 2008. DK Jothimani, MA Anderson, PG Wilson
• Prevalence of raised ALT in patients with type 2 diabetes mellitus. Midlands Gastro Scientific Meeting, June 2008 DK Jothimani, P De, BT Cooper
• Should we biopsy all gastritis?- A case report. Midlands Gastro Scientific Meeting, June 2008 DK Jothimani, U Zanetto, RG Owens, PG Wilson
• Bleeding but no blood- A case report. Midlands Gastro Scientific Meeting, November 2007 DK Jothimani, R Murrin, MV Lewis
• Control of Clostridium Associated Diarrhoea (CDAD) in a District Hospital in the UK. UEGW Paris, October 2007. DK Jothimani, S Jones, S Manjunath
• Effect of TPN Monitoring Protocol in a DGH- A Three Year Experience. UEGW Paris, October 2007 DK Jothimani, M Askey, SD Hearing
Oral Presentations
• NASH for diabetologist – Chennai Diabetic Association 2019
• Post Liver Transplant Management Gut club Kolkata, Gut Club Trivandrum 2019
• Cirrhotic Cardiomyopathy and its role in critical care. INASL 2018
• Hepatitis E in post liver transplant patients, WCOG, Abu Dhabi 2016
• Acute Liver Failure due to Yellow Phosphorous poisoning. ILTS 2014. London.
• Debate- Role of N-Acetyl cysteine in Non-paracetamol acute liver failure. INASL, Jaipur. 2014
• Management of Acute liver failure. INASL, Hyderabad 2013
• Outcome in the management of CLKT- a single centre experience. ISOT Mumbai October 2012
• New molecular pathogenesis and prognostication in HCC. INASL Gawhati 2012
• Drug induced liver injury, UHCW, November 2010
• Practice of ERCP in Southwest England, Southwest Gastroenterology & Hepatology meeting, Newquay, June 2010
• Role of MMF in Autoimmune hepatitis patients intolerant to Azathioprine, Southwest Gastroenterology & Hepatology meeting, Newquay, June 2010
• Effect of weight loss on antiviral treatment response in obese chronic hepatitis C patients- BILG meeting, Brisbane, April 2009
• Control of CDAD in Manor Hospital- A Follow-up data Midlands Gastro Scientific Meeting, June 2007
• Benign biliary Strictures, Gut Club, February 2006
• Outcome of paracetamol overdose referred to QE UHB, Birmingham – April 2005
Courses and Conferences attended
• Master Class in Liver Disease (Chennai) 2012- till date (annual meet)
• EASL conference 2016, Barcelona
• International Liver Transplant society (ILTS), 2014 and 2017 London
• European Association for the Study of Liver (EASL)- 2014 London
• Indian Society of Organ Transplantation October 2012
• INASL 2012- till date (Annual meeting)
• Best of DDW June 2011, Hyderabad
• APASL February 2011, Bangko
• ERCP course (hands on) October 2010, Stoke-on Trent
• BASL Liver conference September 2010, Edinburgh
• BASL School of Hepatology July 2010, Cambridge
• Southwest Gastroenterology June 2010, Newquay & Hepatology meeting
• King’s Liver course April 2010, London
• BASL liver conference October 2009, London
• Coolum Queensland June 2009, Queensland Hepatology meeting
• Non-invasive markers of May 2009, Melbourne Liver fibrosis meeting
• Brisbane liver group October 2008, April 2009 Brisbane (BILG) meeting
• Case by case meeting January 2009, Sydney (Hepatitis B)
• Australian Gastroenterology October 2008, Brisbane week
• Leadership & Management July 2008, Warwick Medical school course
• BSG conference 2005, 2006, 2008
• UEGW conference October 2007, Paris
• Midlands Gastro Scientific June & November 2005, 2006, June & November 2007, June 2008
• National Gastroenterology April 2007, Edinburgh Conference
• Upper GI endoscopy course June 2005 Wolverhampton
• Medical Emergencies October 2002 UCL London
Clinical Expertise
Dr. Dinesh Jothimani is a liver specialist trained in the UK and Australia. He cares for his patients who suffer from liver diseases and performs skillful liver transplants. He carries our endoscopic procedures including ERCPs and therapeutic endoscopies. His interests are Acute Liver Failure, Liver Transplantation, Viral Hepatitis, Autoimmune Hepatitis & ERCP.
Procedures Performed Competent practitioner
• ERCP (total 500)
• OGD (diagnostic and therapeutic) (total >1000)
• Colonoscopy (total 600)
• Transient elastography (Fibroscan)
• Percutaneous Liver Biopsy (>350)
• Abdominal paracentesis
• Central lines (internal jugular, subclavian, femoral and long lines)
• Arterial line
• Swan-Ganz catheter
• Temporary pacing wire insertion
• DC cardioversion (emergency)
Laboratory Skills
• Immunohistochemistry
• Immunofluorescence
• RT-PCR and bench PCR
• Reverse Transcription
• Gel Electrophoresis and restriction enzyme digestion
Experience
Current Position
• 12th September 2018 – till date – Director of Hepatology, Dr Rela Hospital, Chennai
Previous Position
• 4th Aug 2012 – September 2018 – Consultant Liver Transplant Physician. Institute of Liver disease and Transplantation. Global Hospitals, Chennai
• 1st Oct 2010 – 1st Feb 2011 – Consultant Hepatologist, University Hospitals of Coventry & Warwickshire (Locum)
• 1st Sep 2010 – 30th Sep 2010 – Specialist Registrar Rotation WMD/018/517 Gastroenterology/G(I)M. West Midlands Deanery, Russell’s hall hospital, Dudley
• 1st Sep 2009 – 30th Aug 2010 – Specialist Registrar Hepatology (NTN) (RCP accredited) South west Liver Unit, Derriford Hospital, Plymout
• 4th August 2008 to 3rd Aug 2009 – Hepatology Research Fellow, Princess Alexandra Hospital, Brisbane, Australia
• 1st August 2007 to 1st August 2008 – Honorary Hepatology Research Fellow, Liver labs, Institute of Biomedical Research. University of Birmingham
• 4th June 2007 to 4th Aug 2008 – Specialist Registrar Rotation WMD/018/517 , Gastroenterology/G(I)M. West Midlands Deanery, City Hospital, Birmingham
• 6th June 2006 to 3rd June 2007 – Specialist Registrar Rotation WMD/018/517, Gastroenterology/G(I)M. West Midlands Deanery, Manor Hospital, Walsal
• 6th June 2005 to 5th June 2006 – Specialist Registrar Rotation WMD/018/517, Gastroenterology/G(I)M. West Midlands Deanery, Mid-Staffordshire General Hospital, Stafford
• 16th August 2004 to 5th June 2005 – Specialist Registrar Rotation WMD/018/517, Hepatology. West Midlands Deanery. Liver Unit- Queen Elizabeth Hospital, Birmingham
• 6th August 2002 to 4th August 2004 – Senior House Officer – Medical Rotation, Sherwood Forest NHS Trust – Kings Mill Hospital
• 6th February 2002 to 5th August 2002 – Senior House Officer – General Medicine, Birmingham Heartlands & Solihull NHS Trust
• 1st August 2001 to 5th February 2002 – House Officer – General Medicine, Medway Maritime Hospital, Gillingham, Kent
• 21st June 2001 to 31st July 2001 – Senior House Officer – Nephrology, Leicester General Hospital. University Hospitals of Leicester, Leicester
• 26th February 2001 to 26th April 2001 – Clinical Observership, Accident & Emergency, Kettering General Hospital, Kettering, Northants
• 1st May 2000 to 30th October 2000 – Senior House Officer – General Medicine, Madras Medical College & Govt. General Hospital, Madras (Chennai) India
• 28th January 1999 to 27th January 2000 – Pre Registration House Officer, Madras Medical College & Govt. General Hospital, Madras India